Cross-Presentation by Dendritic Cells in Oxidized Lipids Block Antigen
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چکیده
منابع مشابه
Lipid peroxidation causes endosomal antigen release for cross-presentation.
Dendritic cells (DCs) present foreign antigen in major histocompatibility complex (MHC) class I molecules to cytotoxic T cells in a process called cross-presentation. An important step in this process is the release of antigen from the lumen of endosomes into the cytosol, but the mechanism of this step is still unclear. In this study, we show that reactive oxygen species (ROS) produced by the N...
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